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Inherited Kidney Diseases Clinic

Director: Patrick E. Gipson, M.D.

The Inherited Kidney Diseases Clinic in the Division of Nephrology helps diagnose and treat adults with genetically determined kidney diseases. We work closely with patients' local physicians to help coordinate treatment, education and follow-up. Children may be evaluated through the Division of Pediatric Nephrology, with dedicated pediatric nephrologists.

Over 60 genetic diseases are currently known that directly or indirectly affect the kidneys. Of these, some are relatively common. Autosomal Dominant Polycystic Kidney Disease (ADPKD) occurs in 1 in 500 people. It is passed down from parent to child through generations, and is the cause of kidney failure for more than 20,000 people currently living in the United States with many more affected worldwide. Major problems from ADPKD usually occur in adulthood. Other inherited kidney diseases are less common. Autosomal Recessive Polycystic Kidney Disease (ARPKD) affects about 1 in 30,000 people. It generally causes symptoms in early to late childhood. While both of these diseases can cause severe health problems, there are other inherited kidney diseases, such as Thin Basement Membrane Disease, that may be very mild and cause no major problems at all.

At the University of Michigan, clinical nephrologists as well as specialists in genetics, urology, radiology and pathology help address the special issues that may arise from having a kidney disease with a genetic cause.

Additional information about specific diseases is available through the following links:

Autosomal dominant and recessive polycystic kidney disease:
PKD Foundation
Alport Syndrome:
Alport Syndrome Foundation
Lowe Syndrome:
Lowe Syndrome Association
Cystinosis:
Cystinosis Research Network

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