Dr. Weitzel conducts research in many areas of medical device development for application in patients with renal and vascular diseases. Research interests include End Stage Renal Disease, vascular access for dialysis, dialysis access surveillance techniques, bioengineering, and novel imaging modalities including ultrasound strain and elasticity imaging. Dr Weitzel’s research group and collaborators are developing a novel dialysis access surveillance technique (VF Doppler) with ongoing laboratory studies and clinical trials. This research includes development of the prototypes, and software as well as testing measurement validity in the lab and clinically. Clinical studies are in progress to explore monitoring optimization. In the area of imaging, laboratory studies and early human trials are in progress to develop novel imaging methods to measure the mechanical properties of blood vessels, dialysis vascular access, and transplanted kidneys. Other areas of interest include artificial organ technologies and novel dialysis techniques, biopsy needle design and other medical device design.
Link to PubMed Citations
Weitzel WF, Kim K, Park DW, Hamilton J, O'Donnell M, Cichonski TJ, Rubin JM. High-resolution ultrasound elasticity imaging to evaluate dialysis fistula stenosis.
Semin Dial. 2009 Jan-Feb;22(1):84-9.
Weitzel WF, Cotant CL, Wen Z, Biswas R, Patel P, Panduranga H, Gianchandani YB, Rubin JM. Analysis of novel geometry-independent method for dialysis access pressure-flow monitoring.
Theor Biol Med Model. 2008 Nov 5;5:22.
Weitzel WF, Kim K, Henke PK, Rubin JM. High-resolution Ultrasound Speckle Tracking May Detect Vascular Mechanical Wall Changes in Peripheral Artery Bypass Vein Grafts.
Ann Vasc Surg. 2008 Oct 28. [Epub ahead of print]
Wusirika R, Leavitt M, Boyer C, Wilson TJ, Gorrell VL, Segal J, Weitzel WF. Hemodialysis graft with blind loop inflow segment treated with stent placement.
Semin Dial. 2008 Sep-Oct;21(5):455-6.
Weitzel WF. Preoperative hemodialysis fistula evaluation: angiography, ultrasonography and other studies, are they useful?
Contrib Nephrol. 2008;161:23-9. Review.
Rubin JM, Xie H, Kim K, Weitzel WF, Emelianov SY, Aglyamov SR, Wakefield TW, Urquhart AG, O'Donnell M. Sonographic elasticity imaging of acute and chronic deep venous thrombosis in humans.
J Ultrasound Med. 2006 Sep;25(9):1179-86.
Xie H, Kim K, Aglyamov SR, Emelianov SY, O’Donnell M, Weitzel WF, Wrobleski SK, Myers DD, Wakefield TW, and Rubin JM. Correspondence of Ultrasound Elasticity Imaging to Direct Mechanical Measurement in Aging DVT in Rats. Ultrasound in Med Biol. 31(10):1351-1359, 2005
Weitzel WF, Kim K, Rubin JM, Xie H, O’Donnell M. Renal advances in ultrasound elasticity imaging: Measuring the compliance of arteries and kidneys in end-stage renal disease. Blood Purif 23(1):10-17, 2005.
Humes HD, Weitzel WF, Fissell WH. Renal cell therapy in the treatment of patients with acute and chronic renal failure. Blood Purif 22(1):60-72, 2004.
Segal JH, Weitzel WF. Monitoring techniques of vascular access. Contrib Nephrol 142:216-27, 2004.
Saran R, Pisoni RL, Weitzel WF. Epidemiology of vascular access for hemodialysis and related practice patterns. Contrib Nephrol 142:14-28, 2004.
Kim K, Weitzel WF, Rubin JM, Xie H, Chen X, O'Donnell M. Vascular intramural strain imaging using arterial pressure equalization. Ultrasound Med Biol. Jun;30(6):761-71, 2004.
Humes HD, Weitzel WF, Bartlett RH, Swaniker FC, Paganini EP, Luderer JR, Sobota J. Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure. Kidney Int. Oct;66(4):1578-88, 2004.
Xie H, Kim K, Aglyamov SR, Emelianov SY, Chen X, O'Donnell M, Weitzel WF, Wrobleski SK, Myers DD, Wakefield TW, Rubin JM. Staging deep venous thrombosis using ultrasound elasticity imaging: animal model. Ultrasound Med Biol. Oct;30(10):1385-96, 2004.
Weitzel WF, Kim K, Rubin JM, Wiggins RC, Xie H, Chen X, Emelianov SY, O’Donnell M. Feasibility of applying ultrasound strain imaging to detect renal transplant chronic allograft nephropathy. Kidney Int Feb;65(2):733-736, 2004.